Blood omics can predict trauma recovery days before complications
A University of Colorado Anschutz study shows proteomic and metabolomic markers can forecast organ failure and mortality days in advance, validated in a second cohort and accurate in 92% of cases.
- Researchers mapped molecular endotypes and trajectories in more than 1,300 trauma patients using proteomics and metabolomics.
- The study was published in Science Translational Medicine and validated in an independent cohort of over 300 patients with 92% prediction accuracy.
- Omics markers predicted organ failure and mortality more accurately than traditional injury-based measures.
- Researchers are working to adapt the molecular profiling for rapid point-of-care use in emergency and military settings.
- The study was co-led by Mitchell Cohen, Kirk Hansen and Angelo D'Alessandro and funded by the NIH and the Department of Defense.