Two PFAS Linked to Faster Epigenetic Aging in Middle-Aged Men, Study Finds
Feb 26th 2026
A reanalysis of NHANES blood samples links two PFAS chemicals, PFNA and PFOSA, to faster DNA methylation based aging in men aged 50 to 64, but the study cannot prove cause and effect.
- Higher blood levels of PFNA and PFOSA were associated with faster epigenetic aging in men aged 50 to 64.
- Researchers analyzed 326 women and men from NHANES 1999-2000 and estimated biological age using 12 DNA methylation based epigenetic clocks.
- PFNA and PFOSA were detected in about 95 percent of participants.
- The accelerated aging association was seen only in middle-aged men and not in women, despite similar PFAS concentrations across sexes.
- The study shows an association, not proof of causation, and authors call for more research to rule out confounding factors.
- To reduce potential exposure, researchers suggest limiting packaged foods and avoiding microwaving food in fast-food containers; the paper appears in Frontiers in Aging.