The Digester

30-Year Study Finds Food Quality Matters More Than Low-Carb or Low-Fat for Heart Health

Mar 1st 2026

A long-term study of nearly 200,000 US adults shows that eating higher quality foods matters more for heart health than simply cutting carbs or fat, with both healthy low-carb and healthy low-fat patterns linked to better biomarkers and lower coronary heart disease risk.

  • Study tracked nearly 200,000 US adults for about 30 years, totaling roughly 5.2 million person-years.
  • Researchers found diet quality, not just the share of carbs or fats, was the key driver of cardiovascular benefits.
  • Healthy low-carbohydrate and healthy low-fat patterns were both associated with higher HDL and lower blood fats and inflammatory markers.
  • Participants who ate more whole foods, fruits, vegetables, whole grains and healthy fats had a significantly lower risk of coronary heart disease.
  • The study relied on self-reported diets and involved health professionals, which may limit how broadly the results apply.
  • The research was led by Harvard epidemiologist Zhiyuan Wu and published in the Journal of the American College of Cardiology.