health
Man enters HIV remission after bone marrow transplant from CCR5Δ32 sibling
A man achieved functional cure of HIV after a bone marrow transplant from his brother, who has the CCR5Δ32 mutation; extensive testing found no virus in major reservoirs and the patient remains off antiretroviral therapy.
Apr 13th 2026 · Norway
Insights
- A 63-year-old man stopped antiretroviral therapy and showed no detectable HIV after receiving bone marrow from his brother who carries two copies of CCR5Δ32.
- Donor cells replaced the recipient's bone marrow and restored healthy T cell counts within a year.
- Researchers found no detectable HIV in blood, bone marrow, or gut mucosal tissue, a key viral reservoir.
- This is the first reported HIV remission following a transplant from a sibling donor with CCR5Δ32.
- Bone marrow transplants carry serious risks and are only used when patients need transplantation for other medical reasons.
- The result advances understanding of cure mechanisms but is not a broadly applicable HIV treatment at this time.
Sources
- El caso del 'paciente Oslo', la décima curación del VIH a través de un trasplante de células madre www.elmundo.es
- Las lecciones que dejan los 10 ‘curados’ del VIH tras un trasplante de células madre: del icónico caso de Berlín al ‘paciente de Oslo’ elpais.com
- Curat el primer pacient de VIH amb cèl·lules donades per un germà www.ara.cat
- La Fe estrena una unidad para adaptar los tratamientos a la genética del paciente www.abc.es
- Primer caso de ‘curación’ del VIH con un trasplante de células madre procedente de un hermano www.agenciasinc.es
- Un trasplante de células madre logra la curación del décimo paciente de VIH del mundo www.heraldo.es
- De Berlín a Oslo: ya son diez las personas que han logrado derrotar al VIH en el mundo www.abc.es
- Un equipo con participación española logra curar al décimo paciente con VIH del mundo www.20minutos.es
- Person functionally cured of HIV after bone marrow transplant from sibling www.scientificamerican.com
- From the Oslo to the Berlin patient: Lessons learned from 10 people ‘cured’ of HIV english.elpais.com
- Norwegian man effectively cured of HIV after transplant from brother www.dawn.com
- Man ‘cured’ of HIV after brother found to carry rare genetic mutation: ‘Like winning lottery twice’ www.independent.co.uk
- Man with HIV becomes just 10th person to ever be cured after he had stem cell transplant www.independent.co.uk