Randomized trial compares oral water and IV fluids for fluid responsiveness in healthy volunteers
Mar 22nd 2026 ยท France
A French prospective randomized trial tested whether drinking water and intravenous infusion produce different effects on cardiac output and stroke volume in healthy volunteers, with protocol registration, ethics approval and data available on request.
- Prospective randomized study compared oral water ingestion with intravenous fluid infusion in healthy adult volunteers.
- Study was conducted in Amiens and Dijon, France, with ethics approval from CPP Nord Ouest I and registration NCT05153837.
- Primary hemodynamic endpoints included cardiac output and stroke volume measured by transthoracic echocardiography.
- Authors report no competing interests and state that data are available from the corresponding author on reasonable request.
- The paper was published in Scientific Reports on 17 March 2026 and lists multidisciplinary French hospital and university affiliations.