The Digester

An Oxford-led mouse study shows the psychedelic 5-MeO-DMT creates a hybrid brain state with deep-sleep electrical activity and wakeful behavior, suggesting a global reorganization of brain activity that could relate to plasticity and therapeutic effects.

5-MeO-DMT caused large increases in slow-wave activity and neuronal OFF-periods in awake, moving mice.
Mice displayed high pupil dilation and normal wake behaviors despite brain waves typical of deep sleep.
Theta rhythms tied to movement were suppressed while animals remained active.
Blocking specific serotonin receptors prevented pupil dilation and theta suppression but increased slow waves.
Local cortical injection did not reproduce the effects, indicating the state depends on widespread brain networks.
After sleep deprivation, the drug reduced the normal slow-wave rebound and produced a delayed increase in REM sleep over the next 48 hours.

5-MeO-DMT produces a sleep-like brain state in awake mice called 'paradoxical wake'

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