Swiss study finds centenarians' blood proteins resemble those of younger adults
Feb 24th 2026
The SWISS100 project measured 724 serum proteins in 39 centenarians, 59 octogenarians and 40 adults aged 30 to 60 and identified 37 proteins in centenarians linked to slower ageing, notably lower oxidative stress and preserved metabolic markers.
- SWISS100 measured 724 blood proteins across 39 centenarians, 59 octogenarians and 40 adults aged 30 to 60.
- Thirty seven proteins in centenarians had profiles closer to younger adults than to octogenarians, suggesting specific ageing pathways are slowed.
- Centenarians showed markedly lower oxidative stress markers and lower levels of antioxidant proteins, consistent with a reduced free radical burden.
- Several extracellular matrix regulators and lower interleukin-1 alpha indicate preserved tissue maintenance and less inflammation in centenarians.
- Metabolic differences included preserved DPP-4 levels that may help maintain lower insulin and protect against metabolic syndrome.
- The study is published in Aging Cell and the authors note genetics explains about 25 percent of longevity while lifestyle remains a key modifiable factor and the findings could guide future therapies for frailty.